Immunity, Oxidative stress & Pharmacology Immunity
 
· The GliSODin® product and the immune-system:
The immuno-redox concept of GliSODin® is based on the fact that the body organizes innate and specific immune defenses against foreign elements (nutriments, pathogens, drugs etc.) and that these two waves of defence are tightly linked rather than dissociated.

The innate immunity is immediately mobilized upon initial contact with the gliadin coating of GliSODin®. The body recognizes the gliadin as a “heterologous” (or antigenic) material which triggers an immune response. The specific immunity stimulated involves cells, cytokines and antibodies that can attack and destroy the invading agents. The specific immune response is relatively slow but the conferred immunity is long lasting.

Evidence of immuno-modulation by the GliSODin® product: After reaching the intestinal mucosa without being degraded in the intestinal tract, GliSODin® comes into contact with the different components of the immune system and regulates the local and systemic immune functions:

Activation of macrophages and epithelial cells:
GliSODin® was found to stimulate the production of nitric oxide (NO) and to control the production of superoxide anion by gastrointestinal epithelial cells and macrophages. This production of NO in superoxide, anion-free conditions controls the gene and protein expression of various cytokines (TNF, IL-8, etc.) and of anti-oxidant enzymes (extracellular SOD, etc.) thus propagating (via the innate immune system) the pharmacological properties of heterologous SOD (7).

The antigenic nature of the vegetarian SOD also promotes the differentiation of phagocytic cells into specialized dendritic cells that will trigger the specific immune system to promote a “tolerogenic” immune response and thus propagate the pharmacological messages of nutritional SOD’s (tolerance and stimulation of body anti-oxidants)
 
Effect to skin, Red Blood Cells (RBC) and White Blood Cells (WBC) in normal situations.
GliSODin® administration suppressed the destructive process caused by skin fibrosis. GliSODin® intake also stimulated the body’s own SOD production and other anti-oxidant activities in RBC's and WBC's.